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  • Cornell University scientists have announced that apple polyphenol extracts slow mammary tumor growth in rats.

  • "This study demonstrated that whole apple extracts effectively inhibited mammary cancer growth in the rat model"

Apples Prevent Mammary Tumors in Rats, J. Agric. Food Chem, March 2005


 J. Agric. Food Chem, March 2005
Apples Prevent Mammary Tumors in Rats

Rui Hai Liu, Jiaren Liu, and Bingqing Chen

Department of Food Science, and Institute of Comparative and Environmental Toxicology, Stocking Hall, Cornell University, Ithaca, New York 14853-7201

Received for review January 4, 2005. Revised manuscript received February 10, 2005. Accepted February 11, 2005.


Regular consumption of fruits and vegetables has been consistently shown to be associated with reduced risk of developing chronic diseases such as cancer and cardiovascular disease. Apples are commonly consumed and are the major contributors of phytochemicals in human diets. It was previously reported that apple extracts exhibit strong antioxidant and antiproliferative activities and that the major part of total antioxidant activity is from the combination of phytochemicals. Phytochemicals, including phenolics and flavonoids, are suggested to be the bioactive compounds contributing to the health benefits of apples. Here it is shown that whole apple extracts prevent mammary cancer in a rat model in a dose-dependent manner at doses comparable to human consumption of one, three, and six apples a day. This study demonstrated that whole apple extracts effectively inhibited mammary cancer growth in the rat model; thus, consumption of apples may be an effective strategy for cancer protection.

Keywords: Diet and cancer; phytochmicals; cancer prevention; breast cancer; fruits

(more research)
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